Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

Namrata Kumar; Arjan F. Theil; Vera Roginskaya; Yasmin Ali; Michael Calderon; Simon C. Watkins; Ryan P. Barnes; Patricia L. Opresko; Alex Pines; Hannes Lans; Wim Vermeulen; Bennett Van Houten

doi:10.1038/s41467-022-28642-9

Nature Communications (Feb 2022)

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

Namrata Kumar,
Arjan F. Theil,
Vera Roginskaya,
Yasmin Ali,
Michael Calderon,
Simon C. Watkins,
Ryan P. Barnes,
Patricia L. Opresko,
Alex Pines,
Hannes Lans,
Wim Vermeulen,
Bennett Van Houten

Affiliations

Namrata Kumar: Molecular Genetics and Developmental Biology graduate program, University of Pittsburgh School of Medicine
Arjan F. Theil: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40
Vera Roginskaya: UPMC Hillman Cancer Center
Yasmin Ali: Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine
Michael Calderon: Center for Biologic Imaging, University of Pittsburgh
Simon C. Watkins: Center for Biologic Imaging, University of Pittsburgh
Ryan P. Barnes: UPMC Hillman Cancer Center
Patricia L. Opresko: UPMC Hillman Cancer Center
Alex Pines: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40
Hannes Lans: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40
Wim Vermeulen: Department of Molecular Genetics, Oncode Institute, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40
Bennett Van Houten: Molecular Genetics and Developmental Biology graduate program, University of Pittsburgh School of Medicine

DOI: https://doi.org/10.1038/s41467-022-28642-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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