Expression of β-Catenin Marker in Colorectal Cancer Cells after Treatment with Royal Jelly

Abstract

The deregulation of a Wnt/β-catenin signal pathway is common in colorectal cancer, while β-catenin, its crucial component, is the target for the development of many anticancer therapies. Here, we showed that royal jelly, as a well-known beneficial natural product, can affect β-catenin at both the gene and protein level in HCT-116 colorectal cancer cell line. Our results indicate the effectiveness of royal jelly in targeting crucial markers responsible for the development and progression of cancer. Therefore, royal jelly presents a promising agent for the development of supplementary anticancer therapy.

Keywords

• HCT-116 cell line
• qRT-PCR
• immunofluorescence
• nuclear export