Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology

Yifei Ge; Lixue Jiang; Chengru Yang; Qingfu Dong; Chengwu Tang; Yi Xu; Yi Xu; Yi Xu; Yi Xu; Yi Xu; Yi Xu; Yi Xu; Xiangyu Zhong

doi:10.3389/fonc.2024.1449696

Frontiers in Oncology (Nov 2024)

Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology

Yifei Ge,
Lixue Jiang,
Chengru Yang,
Qingfu Dong,
Chengwu Tang,
Yi Xu,
Yi Xu,
Yi Xu,
Yi Xu,
Yi Xu,
Yi Xu,
Yi Xu,
Xiangyu Zhong

Affiliations

Yifei Ge: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Lixue Jiang: Department of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Chengru Yang: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Qingfu Dong: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Chengwu Tang: Department of Hepatopancreatobiliary Surgery, Huzhou Key Laboratory of Translational Medicine, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China
Yi Xu: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Yi Xu: Department of Hepatopancreatobiliary Surgery, Huzhou Key Laboratory of Translational Medicine, First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China
Yi Xu: Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Yi Xu: State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, China
Yi Xu: Fujian Provincial Key Laboratory of Tumor Biotherapy, Fuzhou, Fujian, China
Yi Xu: Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China
Yi Xu: Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China
Xiangyu Zhong: Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China

DOI: https://doi.org/10.3389/fonc.2024.1449696
Journal volume & issue: Vol. 14

Abstract

Read online

Tumor-associated macrophages (TAMs) play a pivotal role in sculpting the tumor microenvironment and influencing cancer progression, particularly through their interactions with various forms of regulated cell death (RCD), including apoptosis, pyroptosis, ferroptosis, and necroptosis. This review examines the interplay between TAMs and these RCD pathways, exploring the mechanisms through which they interact to promote tumor growth and advancement. We examine the underlying mechanisms of these intricate interactions, emphasizing their importance in cancer progression and treatment. Moreover, we present potential therapeutic strategies for targeting TAMs and manipulating RCD to enhance anti-tumor responses. These strategies encompass reprogramming TAMs, inhibiting their recruitment, and selectively eliminating them to enhance anti-tumor functions, alongside modulating RCD pathways to amplify immune responses. These insights offer a novel perspective on tumor biology and provide a foundation for the development of more efficacious cancer therapies.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords