Mediators of Inflammation (Jan 1995)

Tumour necrosis factor-α and adenosine in endotoxin shockleading related cardiovascular symptoms

  • S. Sipka,
  • T. Seres,
  • Z. Dinya,
  • Z. Szekanecz,
  • J. Szentmiklósi,
  • E. Bodolay,
  • G. Szegedi

DOI
https://doi.org/10.1155/S0962935195000731
Journal volume & issue
Vol. 4, no. 6
pp. 454 – 455

Abstract

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We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-α, and interleukin (IL)-10. We suggest that these cytokines may contribute to the terminal SIRS-related arrythmias, impaired myocardial contractility, as well as increased vascular permeability. In addition, the increased production of adenosine, a counter-regulatory mediator of inflammation, may also play a role in cardiodepression. We suggest a relationship between the action of TNF-α , IL-10 and adenosine in the pathogenesis of circulatory symptoms described above.