International Journal of Nanomedicine (Sep 2023)

Can Organoid Model Reveal a Key Role of Extracellular Vesicles in Tumors? A Comprehensive Review of the Literature

  • Zhang Y,
  • Lu A,
  • Zhuang Z,
  • Zhang S,
  • Liu S,
  • Chen H,
  • Yang X,
  • Wang Z

Journal volume & issue
Vol. Volume 18
pp. 5511 – 5527

Abstract

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Yang Zhang,1,2,* Anqing Lu,2– 4,* Zixuan Zhuang,1,2 Su Zhang,5 Sicheng Liu,5 Haining Chen,1,2 Xuyang Yang,1,2 Ziqiang Wang1,2 1Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 3Department of Central Transportation, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 4West China School of Nursing, Sichuan University, Chengdu, 610041, People’s Republic of China; 5Research Laboratory of Tumor Epigenetics and Genomics, Department of General Surgery, Frontiers Science Center for Disease-Related Molecular Network and National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ziqiang Wang; Xuyang Yang, Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China, Email [email protected]; [email protected]: Extracellular vesicles (EVs) are small membrane-bound vesicles that are released by cells into the extracellular environment. The role of EVs in tumors has been extensively studied, and they have been shown to play a crucial role in tumor growth, progression, and metastasis. Past research has mainly used 2D-cultured cell line models to investigate the role of EVs in tumors, which poorly simulate the tumor microenvironment. Organoid technology has gradually matured in recent years. Organoids are similar in composition and behavior to physiological cells and have the potential to recapitulate the architecture and function of the original tissue. It has been widely used in organogenesis, drug screening, gene editing, precision medicine and other fields. The integration of EVs and organoids has the potential to revolutionize the field of cancer research and represents a promising avenue for advancing our understanding of cancer biology and the development of novel therapeutic strategies. Here, we aimed to present a comprehensive overview of studies using organoids to study EVs in tumors.Keywords: organoids, extracellular vesicles, tumors, model, review

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