Dynamics of thyroid gland sizes in patients with diffuse and nodular goiter, autoimmune thyroiditis during monotherapy by Alba® preparation in different regions of Ukraine

Abstract

Background. The purpose of work was to evaluate the dynamics of thyroid volume in patients with autoimmune thyroiditis (АТ), diffuse non-toxic goiter (DNG) and nodular goiter (NG) during monotherapy by herbal preparation Alba® in the different regions of Ukraine. Materials and methods. Research was conducted by endocrinologists in 56 medical institutions of Ukraine. There were patients with АТ, DNG and NG under supervision. Patients received monotherapy by preparation of Alba® during six months at a dose of one capsule twice a day. Before treatment, after 3 and 6 months, thyroid volume (in сm3) was evaluated. Results. Probability of thyroid volume reduction (by 15 % and more for 6 months) in patients with АТ on the background of treatment using Alba® is related to the initial thyroid volume. Probability of achie­ving the effect grows (p = 0.001, odds ratio (OR) = 1.07; 95% confidence interval (CI) 1.03–1.11) on each 1 сm3 of initial volume increase. Probability of thyroid volume reduction (by 15 % and more for 6 months) in patients with DNG after application of Alba® is related to the initial thyroid vo­lume. Probability of achieving the effect grows (p < 0.001, OR = 1.09; 95% CI 1.04–1.14) on each 1 cм3 increase of initial volume. Conclusions. The clinical efficiency of Alba® preparation in terms of reducing thyroid volume was proved in patients with АТ, DNG and NG.

Keywords

• autoimmune thyroiditis
• diffuse non-toxic goiter
• nodular goiter
• root extract of the Potentilla alba
• Alba®