Longitudinal in vivo imaging of acute neuropathology in a monkey model of Ebola virus infection

William Schreiber-Stainthorp; Jeffrey Solomon; Ji Hyun Lee; Marcelo Castro; Swati Shah; Neysha Martinez-Orengo; Rebecca Reeder; Dragan Maric; Robin Gross; Jing Qin; Katie R. Hagen; Reed F. Johnson; Dima A. Hammoud

doi:10.1038/s41467-021-23088-x

Nature Communications (May 2021)

Longitudinal in vivo imaging of acute neuropathology in a monkey model of Ebola virus infection

William Schreiber-Stainthorp,
Jeffrey Solomon,
Ji Hyun Lee,
Marcelo Castro,
Swati Shah,
Neysha Martinez-Orengo,
Rebecca Reeder,
Dragan Maric,
Robin Gross,
Jing Qin,
Katie R. Hagen,
Reed F. Johnson,
Dima A. Hammoud

Affiliations

William Schreiber-Stainthorp: Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH)
Jeffrey Solomon: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research
Ji Hyun Lee: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Marcelo Castro: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Swati Shah: Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH)
Neysha Martinez-Orengo: Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH)
Rebecca Reeder: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Dragan Maric: Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health
Robin Gross: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Jing Qin: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Katie R. Hagen: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Reed F. Johnson: Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Dima A. Hammoud: Hammoud Laboratory, Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH)

DOI: https://doi.org/10.1038/s41467-021-23088-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The neurological effects of Ebola disease in the acute stage are not well-described. Here, the authors use longitudinal in vivo neuroimaging and immunohistochemistry to assess pathological changes in the central nervous system in a non-human primate model of Ebola virus infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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