Chiral phosphoric acid-catalyzed enantioselective phosphinylation of 3,4-dihydroisoquinolines with diarylphosphine oxides

Abstract

Catalytic enantioselective phosphinylation of imines with diarylphosphine oxides is a powerful approach to access chiral α-amino diarylphosphine oxides. Here, the authors report the asymmetric phosphinylation of 3,4-dihydroisoquinolines at the C1 position using diarylphosphine oxides, catalyzed by chiral phosphoric acids.