Nature Communications (Oct 2021)
Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth
- Pamela Pruski,
- Gonçalo D. S. Correia,
- Holly V. Lewis,
- Katia Capuccini,
- Paolo Inglese,
- Denise Chan,
- Richard G. Brown,
- Lindsay Kindinger,
- Yun S. Lee,
- Ann Smith,
- Julian Marchesi,
- Julie A. K. McDonald,
- Simon Cameron,
- Kate Alexander-Hardiman,
- Anna L. David,
- Sarah J. Stock,
- Jane E. Norman,
- Vasso Terzidou,
- T. G. Teoh,
- Lynne Sykes,
- Phillip R. Bennett,
- Zoltan Takats,
- David A. MacIntyre
Affiliations
- Pamela Pruski
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London
- Gonçalo D. S. Correia
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London
- Holly V. Lewis
- March of Dimes Prematurity Research Centre at Imperial College London
- Katia Capuccini
- March of Dimes Prematurity Research Centre at Imperial College London
- Paolo Inglese
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London
- Denise Chan
- March of Dimes Prematurity Research Centre at Imperial College London
- Richard G. Brown
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Lindsay Kindinger
- Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Yun S. Lee
- March of Dimes Prematurity Research Centre at Imperial College London
- Ann Smith
- Faculty of Health and Applied Sciences, University West of England
- Julian Marchesi
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London
- Julie A. K. McDonald
- MRC Centre for Molecular Bacteriology and Infection, Imperial College London
- Simon Cameron
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London
- Kate Alexander-Hardiman
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London
- Anna L. David
- Elizabeth Garrett Anderson Institute for Women’s Health, University College London
- Sarah J. Stock
- MRC Centre for Reproductive Health, University of Edinburgh
- Jane E. Norman
- MRC Centre for Reproductive Health, University of Edinburgh
- Vasso Terzidou
- March of Dimes Prematurity Research Centre at Imperial College London
- T. G. Teoh
- St Mary’s Hospital, Imperial College Healthcare NHS Trust
- Lynne Sykes
- March of Dimes Prematurity Research Centre at Imperial College London
- Phillip R. Bennett
- March of Dimes Prematurity Research Centre at Imperial College London
- Zoltan Takats
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London
- David A. MacIntyre
- March of Dimes Prematurity Research Centre at Imperial College London
- DOI
- https://doi.org/10.1038/s41467-021-26215-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Here, the authors apply DESI-MS, a sample preparation-free, direct on-swab mass spectrometry analytical tool, to profile the cervicovaginal metabolome of two independent cohorts of pregnant women and, combined with matched metataxonomic and immuno-profiling data, show that DESI-MS predicts vaginal microbiota composition and local inflammatory status associated with preterm birth and clinical interventions used during pregnancy.
