Communications Biology (Dec 2021)
IQ-Switch is a QF-based innocuous, silencing-free, and inducible gene switch system in zebrafish
- Jeongkwan Hong,
- Jae-Geun Lee,
- Kyung-Cheol Sohn,
- Kayoung Lee,
- Seoee Lee,
- Jinyoung Lee,
- Jihye Hong,
- Dongju Choi,
- Yeseul Hong,
- Hyo Sun Jin,
- Dae-Kyoung Choi,
- Su Ui Lee,
- Yun Kee,
- Jangham Jung,
- Young-Ki Bae,
- Ran Hee Hwang,
- Gang Min Hur,
- Jeong-Soo Lee,
- Hyunju Ro
Affiliations
- Jeongkwan Hong
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Jae-Geun Lee
- Disease Target Structure Research Center, KRIBB, 125 Gwahak-ro, Yuseong-gu
- Kyung-Cheol Sohn
- Department of Pharmaclogy, College of Medicine, Chungnam National University
- Kayoung Lee
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Seoee Lee
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Jinyoung Lee
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Jihye Hong
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Dongju Choi
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Yeseul Hong
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Hyo Sun Jin
- Biomedical Research Institute, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu
- Dae-Kyoung Choi
- Biomedical Research Institute, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu
- Su Ui Lee
- Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
- Yun Kee
- Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University
- Jangham Jung
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- Young-Ki Bae
- Division of Cancer Biology, Research Institute, National Cancer Center
- Ran Hee Hwang
- Department of Nursing, Gwangju Women’s University
- Gang Min Hur
- Department of Pharmaclogy, College of Medicine, Chungnam National University
- Jeong-Soo Lee
- Disease Target Structure Research Center, KRIBB, 125 Gwahak-ro, Yuseong-gu
- Hyunju Ro
- Department of Biological Science, College of Biosciences and Biotechnology, Chungnam National University
- DOI
- https://doi.org/10.1038/s42003-021-02923-3
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Hong et al. describe a new transgene expression system, IQ-Switch, and its variants and characterize their applications in cell culture and zebrafish systems. They show that IQ-Switch system has several advantages over the previous inducible transgene expression switches, including the low toxicity, tunability of expression levels and low levels of gene silencing.
