Chronobiotics KL001 and KS15 Extend Lifespan and Modify Circadian Rhythms of <i>Drosophila melanogaster</i>

Abstract

Chronobiotics are a group of drugs, which are utilized to modify circadian rhythms targeting clock-associated molecular mechanisms. The circadian clock is known as a controller of numerous processes in connection with aging. Hypothesis: KL001 and KS15 targeting CRY, affect lifespan, locomotor activity and circadian rhythm of Drosophila melanogaster. We observed a slight (2%, p p p p p < 0.0001). This phenomenon may suggest the presence of the mechanism associated with improvement of fat body glucose depos’ utilization in starvation conditions which is activated by dCRY binding KL001.

Keywords

• chronobiotics
• geroprotectors
• cryptochrome
• KL001
• KS15
• <i>Drosophila melanogaster</i>