Фармакокинетика и Фармакодинамика (Mar 2018)

The possibility of using echocardiography in small laboratory animals for acute pharmacological tests

  • E. O. Ionova,
  • I. B. Tsorin,
  • V. V. Barchukov,
  • V. N. Stolyaruk,
  • S. A. Kryzhanovskii

DOI
https://doi.org/10.24411/2587-7836-2018-10015.
Journal volume & issue
Vol. 0, no. 2
pp. 59 – 64

Abstract

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Resume. The purpose of this investigation is to study the adequacy of the echocardiography method in small laboratory animals for performing acute pharmacological tests. In experiments on white mongrel male rats, a nonselective ß-adrenoreceptor agonist isoproterenol (20 μg /kg, i.v.) reduces the end-systolic and end-diastolic dimensions and volumes of the heart left ventricle, measured by echocardiography, and increases the shortening and ejection fractions, i.e. has a positive inotropic effect. Cardioselective ß1-adrenoblocker metoprolol (1 mg / kg, i.v.), on the contrary, increases the left ventricle sizes and reduces the shortening and ejection fractions, i.e. has a negative inotropic effect. Thus, the method of echocardiography in small laboratory animals can be used to conduct acute pharmacological tests.

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