Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity
Siming Ma,
Sang-Goo Lee,
Eun Bae Kim,
Thomas J. Park,
Andrei Seluanov,
Vera Gorbunova,
Rochelle Buffenstein,
Javier Seravalli,
Vadim N. Gladyshev
Affiliations
Siming Ma
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Sang-Goo Lee
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Eun Bae Kim
Department of Bioinspired Science, Ewha Womans University, Seoul 120-750, Republic of Korea
Thomas J. Park
Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
Andrei Seluanov
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Vera Gorbunova
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Rochelle Buffenstein
Department of Physiology and The Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
Javier Seravalli
Redox Biology Center and Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
Vadim N. Gladyshev
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Trace elements are essential to all mammals, but their distribution and utilization across species and organs remains unclear. Here, we examined 18 elements in the brain, heart, kidney, and liver of 26 mammalian species and report the elemental composition of these organs, the patterns of utilization across the species, and their correlation with body mass and longevity. Across the organs, we observed distinct distribution patterns for abundant elements, transition metals, and toxic elements. Some elements showed lineage-specific patterns, including reduced selenium utilization in African mole rats, and positive correlation between the number of selenocysteine residues in selenoprotein P and the selenium levels in liver and kidney across mammals. Body mass was linked positively to zinc levels, whereas species lifespan correlated positively with cadmium and negatively with selenium. This study provides insights into the variation of mammalian ionome by organ physiology, lineage specialization, body mass, and longevity.
