Frontiers in Pharmacology (Nov 2023)

Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

  • Shiyu Yang,
  • Heming Chen,
  • Wei Su,
  • Yunchun Luo,
  • Jun Liao,
  • Yun Wang,
  • Liyan Xiong,
  • Chuan Zhang,
  • Fei Li,
  • Zhe-Sheng Chen,
  • Tingfang Wang

DOI
https://doi.org/10.3389/fphar.2023.1297124
Journal volume & issue
Vol. 14

Abstract

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Ischemia-reperfusion (I/R) injury refers to a new injury caused by reperfusion after the restoration of ischemic tissue or organ blood supply. Salvianic acid A (danshensu) is a primary active ingredient extracted from Salvia miltiorrhiza. It has a protective function against I/R injury in the cardiovascular system, brain, liver, kidney, gastrointestinal tract, and other organs. This article reviews evidence of the protective effects of Salvianic acid A and its potential mechanisms of action in organ I/R injury protection. The aim of this review is to investigate the role of Salvianic acid A in the treatment of I/R injury, providing a reference resource that could facilitate subsequent studies.

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