Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response

Abstract

Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is one of these approaches. The aim of this study was to determine, whether gene electrotransfer of plasmid encoding shRNA for silencing endoglin, with vascular targeted effectiveness, can radiosensitize melanoma B16F10 tumors.

Keywords

• gene therapy
• electrotransfer
• plasmid
• irradiation
• immune response
• melanoma