Nature Communications (Jun 2021)
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
- Elina A. Pietilä,
- Jordi Gonzalez-Molina,
- Lidia Moyano-Galceran,
- Sanaz Jamalzadeh,
- Kaiyang Zhang,
- Laura Lehtinen,
- S. Pauliina Turunen,
- Tomás A. Martins,
- Okan Gultekin,
- Tarja Lamminen,
- Katja Kaipio,
- Ulrika Joneborg,
- Johanna Hynninen,
- Sakari Hietanen,
- Seija Grénman,
- Rainer Lehtonen,
- Sampsa Hautaniemi,
- Olli Carpén,
- Joseph W. Carlson,
- Kaisa Lehti
Affiliations
- Elina A. Pietilä
- Individualized Drug Therapy Research Program, Research Programs Unit, University of Helsinki
- Jordi Gonzalez-Molina
- Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet
- Lidia Moyano-Galceran
- Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet
- Sanaz Jamalzadeh
- Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki
- Kaiyang Zhang
- Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki
- Laura Lehtinen
- Research Center for Cancer, Infections and Immunity, Institute of Biomedicine, University of Turku
- S. Pauliina Turunen
- Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet
- Tomás A. Martins
- Individualized Drug Therapy Research Program, Research Programs Unit, University of Helsinki
- Okan Gultekin
- Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet
- Tarja Lamminen
- Research Center for Cancer, Infections and Immunity, Institute of Biomedicine, University of Turku
- Katja Kaipio
- Research Center for Cancer, Infections and Immunity, Institute of Biomedicine, University of Turku
- Ulrika Joneborg
- Department of Women’s and Children’s Health, Division Obstetrics and Gynaecology, Karolinska Institutet
- Johanna Hynninen
- Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku
- Sakari Hietanen
- Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku
- Seija Grénman
- Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku
- Rainer Lehtonen
- Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki
- Sampsa Hautaniemi
- Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki
- Olli Carpén
- Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki
- Joseph W. Carlson
- Department of Oncology-Pathology, Karolinska Institutet
- Kaisa Lehti
- Individualized Drug Therapy Research Program, Research Programs Unit, University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-021-24009-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Platinum chemotherapy is standard of care in ovarian cancers but treatment resistance commonly develops. Here, the authors show that the extracellular microenvironment is modulated following chemotherapy and the changes in matrix proteins and stiffness alter the cell death response of tumour cells.
