Evaluation of brain structure abnormalities in children with autism spectrum disorder (ASD) using structural magnetic resonance imaging

Abstract

Abstract Background Autism spectrum disorder (ASD) is a group of developmental disorders of the nervous system. Since the core cause of many of the symptoms of autism spectrum disorder is due to changes in the structure of the brain, the importance of examining the structural abnormalities of the brain in these disorder becomes apparent. The aim of this study is evaluation of brain structure abnormalities in children with autism spectrum disorder (ASD) using structural magnetic resonance imaging (sMRI). sMRI images of 26 autistic and 26 Healthy control subjects in the range of 5–10 years are selected from the ABIDE database. For a better assessment of structural abnormalities, the surface and volume features are extracted together from this images. Then, the extracted features from both groups were compared with the sample t test and the features with significant differences between the two groups were identified. Results The results of volume-based features indicate an increase in total brain volume and white matter and a change in white and gray matter volume in brain regions of Hammers atlas in the autism group. In addition, the results of surface-based features indicate an increase in mean and standard deviation of cerebral cortex thickness and changes in cerebral cortex thickness, sulcus depth, surface complexity and gyrification index in the brain regions of the Desikan–Killany cortical atlas. Conclusions Identifying structurally abnormal areas of the brain and examining their relationship to the clinical features of Autism Spectrum Disorder can pave the way for the correct and early detection of this disorder using structural magnetic resonance imaging. It is also possible to design treatment for autistic people based on the abnormal areas of the brain, and to see the effectiveness of the treatment using imaging.

Keywords

• ASD
• sMRI
• ABIDE
• Children
• Brain