Frontiers in Bioengineering and Biotechnology (Sep 2022)

Evaluation of antibacterial property and biocompatibility of Cu doped TiO2 coated implant prepared by micro-arc oxidation

  • Binbin kang,
  • Dongmei Lan,
  • Chao Yao,
  • Ping Liu,
  • Xiaohong Chen,
  • Shengcai Qi,
  • Shengcai Qi

DOI
https://doi.org/10.3389/fbioe.2022.941109
Journal volume & issue
Vol. 10

Abstract

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In order to enhance osteogenic differentiation and antibacterial property of dental implants, volcano-shaped microporous TiO2 coatings doped with Cu were fabricated via micro-arc oxidation (MAO) on Ti. Cu-doped coating with different mass ratios of Cu were obtained by changing the concentration of copper acetate in the electrolyte. The structure of Cu-TiO2 coatings were systematically investigated. Element Copper was uniformly distributed throughout the coating. Compared with TiO2 coating, the Cu-doped can further improved proliferation of bone mesenchymal stem cells (BMSCs), facilitated osteogenic differentiation. The bacteriostasis experiments demonstrated that Cu-doped TiO2 coating possess excellent antibacterial property against Staphylococcus aureus (S. aureus) and Porphyromonas gingivalis (P. gingivalis).

Keywords