Current Chemistry Letters (Jun 2019)
Synthesis of supramolecular receptors for amino acid recognition
Abstract
The derivatives of 2,6-dihydroxyacetophenone[4]arene were synthesized via one-step in the presence of base catalyzed cyclocondensation reaction of equimolar volumes of different aliphatic aldehydes and 2,6-dihydroxyacetophenone. All the compounds were purified by column chromatography and characterized by 1H-NMR Spectroscopy, 13C-NMR Spectroscopy, IR Spectroscopy, and Mass spectrometry techniques. The compounds were provided with good yield and can be successfully useful for various amino acid detection because of the four ketone groups in 2,6-Dihydroxyaceto-phenone[4]arene were able to react with the amino group of amino acid to give a stable product formation. It was caused by the intermolecular hydrogen bonded between the two groups, ketone and carboxylic group of amino acid. This recognition of amino acid was carried out in UV-vis spectroscopic technique.
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