Biocompatibility of magnetic iron oxide nanoparticles for biomedical applications

Abstract

Magnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers. The present study aims at assessing in vitro biocompatibility of two commercially available magnetic iron oxide nanoparticle formulations: dextran-based magnetic nanoparticle synomag-D and bionized nanoferrite BNF-starch. Biological performance of both nanoparticle formulations were studied in human endothelial cells by analyzing cell viability and nanoparticle internalization in order to judge their suitability as theranostics.

Keywords

• magnetic nanoparticle
• magnetic particle imaging
• human endothelial cells
• biocompatibility
• internalization
• cellular uptake