Nature Communications (Aug 2018)

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

  • Camilo E. Quevedo,
  • Abimael Cruz-Migoni,
  • Nicolas Bery,
  • Ami Miller,
  • Tomoyuki Tanaka,
  • Donna Petch,
  • Carole J. R. Bataille,
  • Lydia Y. W. Lee,
  • Phillip S. Fallon,
  • Hanna Tulmin,
  • Matthias T. Ehebauer,
  • Narcis Fernandez-Fuentes,
  • Angela J. Russell,
  • Stephen B. Carr,
  • Simon E. V. Phillips,
  • Terence H. Rabbitts

DOI
https://doi.org/10.1038/s41467-018-05707-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Intracellular antibodies can inhibit disease-relevant protein interactions, but inefficient cellular uptake limits their utility. Using a RAS-targeting intracellular antibody as a screening tool, the authors here identify small molecules that inhibit RAS-effector interactions and readily penetrate cells.