Comparative Analysis of Experimental Series of Plague Live Vaccine as for Viability and Thermostability Indices

Abstract

Comparative analysis of specified indices (viability, thermostability) of plague live vaccine preparations, produced in accordance with different biotechnological production schemes, have been carried out. Shown is that the combination of optimal temperature for Yersinia pestis strain EV biomass propagation (21±1) °C as well as optimal concentration proportion of bacteria and stabilizer in suspension with decreased optical density and volume facilitates effectual moisture removal out of preparation, thus stabilizing microbial cells viability index in the process of storage.

Keywords

• plague live vaccine
• viability
• thermostability
• propagation temperature
• quantitative parameters