Nature Communications (Aug 2021)
Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses
- Natalia Ortega,
- Marta Ribes,
- Marta Vidal,
- Rocío Rubio,
- Ruth Aguilar,
- Sarah Williams,
- Diana Barrios,
- Selena Alonso,
- Pablo Hernández-Luis,
- Robert A. Mitchell,
- Chenjerai Jairoce,
- Angeline Cruz,
- Alfons Jimenez,
- Rebeca Santano,
- Susana Méndez,
- Montserrat Lamoglia,
- Neus Rosell,
- Anna Llupià,
- Laura Puyol,
- Jordi Chi,
- Natalia Rodrigo Melero,
- Daniel Parras,
- Pau Serra,
- Edwards Pradenas,
- Benjamin Trinité,
- Julià Blanco,
- Alfredo Mayor,
- Sonia Barroso,
- Pilar Varela,
- Anna Vilella,
- Antoni Trilla,
- Pere Santamaria,
- Carlo Carolis,
- Marta Tortajada,
- Luis Izquierdo,
- Ana Angulo,
- Pablo Engel,
- Alberto L. García-Basteiro,
- Gemma Moncunill,
- Carlota Dobaño
Affiliations
- Natalia Ortega
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Marta Ribes
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Marta Vidal
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Rocío Rubio
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Ruth Aguilar
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Sarah Williams
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Diana Barrios
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Selena Alonso
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Pablo Hernández-Luis
- Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Robert A. Mitchell
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Chenjerai Jairoce
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Angeline Cruz
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Alfons Jimenez
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Rebeca Santano
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Susana Méndez
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Montserrat Lamoglia
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Neus Rosell
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Anna Llupià
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Laura Puyol
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Jordi Chi
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Natalia Rodrigo Melero
- Biomolecular screening and Protein Technologies Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Daniel Parras
- Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Pau Serra
- Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Edwards Pradenas
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB
- Benjamin Trinité
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB
- Julià Blanco
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, UAB
- Alfredo Mayor
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Sonia Barroso
- Occupational Health Department, Hospital Clínic, Universitat de Barcelona
- Pilar Varela
- Occupational Health Department, Hospital Clínic, Universitat de Barcelona
- Anna Vilella
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Antoni Trilla
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Pere Santamaria
- Department of Preventive Medicine and Epidemiology, Hospital Clinic, Universitat de Barcelona
- Carlo Carolis
- Biomolecular screening and Protein Technologies Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
- Marta Tortajada
- Occupational Health Department, Hospital Clínic, Universitat de Barcelona
- Luis Izquierdo
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Ana Angulo
- Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Pablo Engel
- Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Alberto L. García-Basteiro
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Gemma Moncunill
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- Carlota Dobaño
- ISGlobal, Hospital Clínic, Universitat de Barcelona
- DOI
- https://doi.org/10.1038/s41467-021-24979-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Long-term characterisation of SARS-CoV-2 antibody kinetics is needed to understand the protective role of the immune response. Here the authors describe antibody levels and neutralisation activity in healthcare workers over seven months and investigate the role of immunity to endemic human coronaviruses.