Nature Communications (Nov 2022)
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas
- Sibo Zhao,
- Jia Li,
- Huiyuan Zhang,
- Lin Qi,
- Yuchen Du,
- Mari Kogiso,
- Frank K. Braun,
- Sophie Xiao,
- Yulun Huang,
- Jianfang Li,
- Wan-Yee Teo,
- Holly Lindsay,
- Patricia Baxter,
- Jack M. F. Su,
- Adekunle Adesina,
- Miklós Laczik,
- Paola Genevini,
- Anne-Clemence Veillard,
- Sol Schvartzman,
- Geoffrey Berguet,
- Shi-Rong Ding,
- Liping Du,
- Clifford Stephan,
- Jianhua Yang,
- Peter J. A. Davies,
- Xinyan Lu,
- Murali Chintagumpala,
- Donald William Parsons,
- Laszlo Perlaky,
- Yun-Fei Xia,
- Tsz-Kwong Man,
- Yun Huang,
- Deqiang Sun,
- Xiao-Nan Li
Affiliations
- Sibo Zhao
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Jia Li
- Center for Epigenetics & Disease Prevention, Texas A&M University
- Huiyuan Zhang
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Lin Qi
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Yuchen Du
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Mari Kogiso
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Frank K. Braun
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Sophie Xiao
- Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Division of Hematology-Oncology, Neuro-Oncology & Stem Cell transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Northwestern University Feinberg School of Medicine
- Yulun Huang
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Jianfang Li
- Center for Epigenetics & Disease Prevention, Texas A&M University
- Wan-Yee Teo
- Humphrey Oei Institute of Cancer Research, National Cancer Center Singapore
- Holly Lindsay
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- Patricia Baxter
- Texas Children’s Cancer Center, Texas Children’s Hospital, Baylor College of Medicine
- Jack M. F. Su
- Texas Children’s Cancer Center, Texas Children’s Hospital, Baylor College of Medicine
- Adekunle Adesina
- Department of Pathology, Texas Children’s Hospital, Baylor College of Medicine
- Miklós Laczik
- Epigenetic Services
- Paola Genevini
- Epigenetic Services
- Anne-Clemence Veillard
- Epigenetic Services
- Sol Schvartzman
- Epigenetic Services
- Geoffrey Berguet
- Epigenetic Services
- Shi-Rong Ding
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation, Sun Yat-sen University Cancer Center
- Liping Du
- Clinical Cytogenetic Laboratory, Department of Pathology, Northwestern University Feinberg School of Medicine
- Clifford Stephan
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University
- Jianhua Yang
- Texas Children’s Cancer Center, Texas Children’s Hospital, Baylor College of Medicine
- Peter J. A. Davies
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University
- Xinyan Lu
- Clinical Cytogenetic Laboratory, Department of Pathology, Northwestern University Feinberg School of Medicine
- Murali Chintagumpala
- Texas Children’s Cancer Center, Texas Children’s Hospital, Baylor College of Medicine
- Donald William Parsons
- Texas Children’s Cancer Center, Texas Children’s Hospital, Baylor College of Medicine
- Laszlo Perlaky
- Texas Children’s Cancer Center, Texas Children’s Hospital, Baylor College of Medicine
- Yun-Fei Xia
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine; Department of Radiation, Sun Yat-sen University Cancer Center
- Tsz-Kwong Man
- Texas Children’s Cancer Center, Texas Children’s Hospital, Baylor College of Medicine
- Yun Huang
- Center for Epigenetics & Disease Prevention, Texas A&M University
- Deqiang Sun
- Center for Epigenetics & Disease Prevention, Texas A&M University
- Xiao-Nan Li
- Pre-clinical Neuro-oncology Research Program, Texas Children’s Hospital, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34514-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.
