Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

Meng Zhu; Chuen Yan Leung; Marta N. Shahbazi; Magdalena Zernicka-Goetz

doi:10.1038/s41467-017-00977-8

Nature Communications (Oct 2017)

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

Meng Zhu,
Chuen Yan Leung,
Marta N. Shahbazi,
Magdalena Zernicka-Goetz

Affiliations

Meng Zhu: Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge
Chuen Yan Leung: Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge
Marta N. Shahbazi: Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge
Magdalena Zernicka-Goetz: Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge

DOI: https://doi.org/10.1038/s41467-017-00977-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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The molecular trigger that establishes cell polarity in the mammalian embryo is unclear. Here, the authors show that de novo polarisation of the mouse embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases: polarisation of actomyosin followed by the Par complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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