International Journal of General Medicine (May 2021)

Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population

  • Bogari N,
  • Dannoun A,
  • Athar M,
  • Elkhateeb O,
  • Porqueddu M,
  • Allam R,
  • Alamanni F

Journal volume & issue
Vol. Volume 14
pp. 1699 – 1707

Abstract

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Neda Bogari,1 Anas Dannoun,1 Mohammad Athar,1,2 Osama Elkhateeb,3,4 Massimo Porqueddu,5,6 Reem Allam,7 Francesco Alamanni6 1Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; 2Science and Technology Unit, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; 3Department of Cardiology, King Abdullah Medical City Makkah, Makkah, Kingdom of Saudi Arabia; 4Department of Cardiology, Dalhousie University Halifax, Nova Scotia, Canada; 5Department of Cardiac Surgery, King Fahd Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia; 6Department of Cardiac Surgery, Monzino Heart Center, University of Milan, Milano, Italy; 7Clinical Pathology Department, Faculty of Medicine, Zagazig University, Sharkia, EgyptCorrespondence: Neda BogariDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi ArabiaTel + 966 25270000 Ext:5057-4168Fax +966 25272155Email [email protected] AllamClinical Pathology Department, Faculty of Medicine, Zagazig University, Sharkia, EgyptEmail [email protected]: Coronary artery disease (CAD) is one of the most important leading causes of morbidity and mortality worldwide. Few studies have been carried out in the Saudi population regarding the association of rs10757278 polymorphism with CAD. This study aimed to investigate the association of the rs10757278 polymorphism with CAD in Saudi population.Materials and Methods: In this case-control study, we recruited 437 patients with CAD and 251 cross-matched healthy controls and performed polymorphism genotyping for rs10757278 using a polymerase chain reaction followed by a restriction fragment length polymorphism analysis.Results: The G allele (OR-1.44; 95% CI: 1.15– 1.80; p=0.001), as GG (OR-2.13; 95% CI: 1.35– 3.36; p=0.0009), in the dominant (OR-1.47; 95% CI: 1.03– 2.10; p=0.03) and recessive mode (OR-1.84; 95% CI: 1.26– 2.70; p=0.001) of inheritance showed a high-risk association. A disease stratified risk analysis was conducted and comparisons were made using an ANOVA analysis. Diabetes showed a risk association (p=0.001). However, a regression analysis confirmed that for the CAD cases, there was an association between the GG genotype and diabetes (p=0.005).Conclusion: The results of this study suggest that the polymorphism rs10757278 is related to a high risk of CAD in a Saudi population.Keywords: coronary artery disease, 9p21, rs10757278, gene polymorphism and Saudi population

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