Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

Pam Speight; Michael Kofler; Katalin Szászi; András Kapus

doi:10.1038/ncomms11642

Nature Communications (May 2016)

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

Pam Speight,
Michael Kofler,
Katalin Szászi,
András Kapus

Affiliations

Pam Speight: Keenan Research Centre for Biomedical Science of St Michael’s Hospital, University of Toronto
Michael Kofler: Keenan Research Centre for Biomedical Science of St Michael’s Hospital, University of Toronto
Katalin Szászi: Keenan Research Centre for Biomedical Science of St Michael’s Hospital, University of Toronto
András Kapus: Keenan Research Centre for Biomedical Science of St Michael’s Hospital, University of Toronto

DOI: https://doi.org/10.1038/ncomms11642
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 17

Abstract

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MRTF and TAZ are mechanosensitive transcriptional coactivators, but how they functionally interact is not clear. Here the authors show that MRFT and TAZ exhibit multilevel crosstalk in expression, transport and transcriptional activity; furthermore, TAZ confers sensitivity to TGFβ activation of the smooth muscle actin promoter.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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