SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy

Abstract

A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations.

Keywords

• coronavirus disease
• COVID-19
• severe acute respiratory syndrome coronavirus 2
• SARS-CoV-2
• coronaviruses
• viruses