Nature Communications (Feb 2016)
Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
- Zina Dubeykovskaya,
- Yiling Si,
- Xiaowei Chen,
- Daniel L. Worthley,
- Bernhard W. Renz,
- Aleksandra M. Urbanska,
- Yoku Hayakawa,
- Ting Xu,
- C. Benedikt Westphalen,
- Alexander Dubeykovskiy,
- Duan Chen,
- Richard A. Friedman,
- Samuel Asfaha,
- Karan Nagar,
- Yagnesh Tailor,
- Sureshkumar Muthupalani,
- James G. Fox,
- Jan Kitajewski,
- Timothy C. Wang
Affiliations
- Zina Dubeykovskaya
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Yiling Si
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Xiaowei Chen
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Daniel L. Worthley
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Bernhard W. Renz
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Aleksandra M. Urbanska
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Yoku Hayakawa
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Ting Xu
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- C. Benedikt Westphalen
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Alexander Dubeykovskiy
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Duan Chen
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology
- Richard A. Friedman
- Department of Biomedical Informatics, Irving Cancer Research Center, Columbia University
- Samuel Asfaha
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Karan Nagar
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Yagnesh Tailor
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- Sureshkumar Muthupalani
- Department of Biological Engineering, Division of Comparative Medicine, Massachusetts Institute of Technology
- James G. Fox
- Department of Biological Engineering, Division of Comparative Medicine, Massachusetts Institute of Technology
- Jan Kitajewski
- Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University
- Timothy C. Wang
- Division of Digestive and Liver Disease, Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University
- DOI
- https://doi.org/10.1038/ncomms10517
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid cells and cancer progression.
