Haseki Tıp Bülteni (Dec 2016)

The Acute Effect of Erythropoietin on Mean Platelet Volume Levels during Hypoxia Reoxygenation Injury in Rats

  • Constantinos Tsompos,
  • Constantinos Panoulis,
  • Konstantinos Toutouzas,
  • George Zografos,
  • Aggeliki Triantafyllou,
  • Apostolos Papalois

DOI
https://doi.org/10.4274/haseki.3370
Journal volume & issue
Vol. 54, no. 4
pp. 199 – 206

Abstract

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Aim: This biomedical study tested the effect of erythropoietin (Epo) in rat model, especially in a hypoxia-reoxygenation one. The trend of this factor was evaluated hematologically using serum mean platelets volume (MPV) values. Methods: Forty rats with a mean mass 247.7 g were used. MPV values were evaluated at 60 min (for groups A and C) and at 120 min (for groups B and D) of reoxygenation. Epo was provided only in groups C and D. Results: Epo administration non-significantly lowered the MPV levels by 0.12% +2.13% (p=0.9513). Reoxygenation time non-significantly augmented the MPV levels by 1.37%+2.11% (p=0.4873). However, Epo administration together with reoxygenation time non-significantly reduced the MPV levels by 0.27%+0.92% (p=0.7585). Conclusion: Epo administration had a non-significant short-time decline effect on MPV levels.

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