Impact of metagenomic next-generation sequencing on clinical decision-making at an academic medical center, a retrospective study, Iowa, 2020–2022

Michael Olthoff; Takaaki Kobayashi; Meredith G. Parsons; Bradley Ford; Kunatum Prasidthrathsint; Lemuel Non; Jorge L. Salinas; Daniel J. Diekema; Dilek Ince

doi:10.1017/ash.2024.31

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2024)

Impact of metagenomic next-generation sequencing on clinical decision-making at an academic medical center, a retrospective study, Iowa, 2020–2022

Michael Olthoff,
Takaaki Kobayashi,
Meredith G. Parsons,
Bradley Ford,
Kunatum Prasidthrathsint,
Lemuel Non,
Jorge L. Salinas,
Daniel J. Diekema,
Dilek Ince

Affiliations

Michael Olthoff: Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Takaaki Kobayashi: ORCiD; Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Meredith G. Parsons: Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Bradley Ford: Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Kunatum Prasidthrathsint: Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Lemuel Non: ORCiD; Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Jorge L. Salinas: Department of Internal Medicine, Stanford University, Stanford, CA, USA
Daniel J. Diekema: Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA Department of Medicine, Maine Medical Center, Portland, ME, USA
Dilek Ince: ORCiD; Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA

DOI: https://doi.org/10.1017/ash.2024.31
Journal volume & issue: Vol. 4

Abstract

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We assessed the impact of metagenomic next-generation sequencing (mNGS) on patient care using previously established criteria. Among 37 patients receiving mNGS testing, 16% showed results that had a positive clinical impact. While mNGS results may offer valuable supplementary information, results should be interpreted within the broader clinical context and evaluation.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

About the journal