Propylthiouracil induced leukocytoclastic vasculitis: A rare manifestation

Abstract

Propylthiouracil (PTU) is a common drug used in patients with hyperthyroidism. It may cause perinuclearantineutrophil cytoplasmic antibodies (p-ANCA) in few patients with Graves′ disease. This antibody has been associated with different forms of vasculitis. We report a patient who presented with cutaneous manifestations of leukocytoclasticvasculitis with simultaneous development of p-ANCAs during PTU therapy for Graves′ disease.

Keywords

• Propylthiouracil
• perinuclearantineutrophil cytoplasmic antibodies
• graves′ disease
• vasculitis