Italian Journal of Medicine (Nov 2023)

Lung damages of malaria: a differential diagnosis and treatment in emergency room of a rare case

  • Novella Carannante,
  • Sabrina Scarica,
  • Raffaele Disarno,
  • Gerardo Langella,
  • Pierpaolo Di Micco,
  • Giuseppe Fiorentino

DOI
https://doi.org/10.4081/itjm.2023.1603
Journal volume & issue
Vol. 17, no. 3

Abstract

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Pulmonary involvement occurs in 3 to 10% of the cases of Plasmodium falciparum malaria and represents the most severe complication of this infection, with a lethality of about 70%. The antigens released by the parasite play an important role in the induction and worsening of lung damage. Capillary endothelial cells, which control the flux of fluids to the interstitial space, appear to be the most complicated structures. The clinical manifestations of pulmonary involvement may start suddenly at any time during the course of malaria, even after the disappearance of the circulating parasite. Hyperparasitemia predisposes to these factors. Treatment with corticosteroids is optional, and that is not often a benefit.

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