The effects of zolpidem medicine on thyroid plasmic hormones of T3, T4 and TSH in male mature rats

Abstract

Introduction:Zolpidem drugs, as a GABA agonist, is one of the antidepressant and hypnotic drugs. Based on the results of the studies, excessive amounts of this drug could affect the amount of normal endocrine activity and its metabolic activities. Hence, there was an attempt in this study to measure the levels of hormonal axis hypothalamus – pituitary – thyroid hormone plasma in adult male rats.Material and Methods:In this research, 50 male mature rats with the weight of 200±10 grams were enrolled as the experiment, witness and control groups. The experimental group was divided into 3 subgroups and 150, 300 and 450 ml per kg of zolpidem was administered orally for 21 days. 0.2 ml distilled water was given to the witness group, but the control group did not receive anything. At the end of 21 days, blood sample was taken from the heart ventral areas and the density of the hormones of T3, T4 and TSH were measured using Eliza method and the commercial kits. The results were evaluated using independent T-test.Results:According to the results of this study, the density of T3 hormones in the experiment group did not show any meaningful differences with the control group, while the density of T4 and TSH hormones showed a meaningful decrease in the experiment and control groups (P<0.05).Conclusion:The results obtained from this study showed that zolpidem affects the hypothalamus, pituitary and also thyroid glands. According to the results of the research conducted, there is a possibility that zolpidem has this effect through an increase in prolactin exudation, leading to TRH exudation and decrease in TSH and thyroid hormones.

Keywords

• Zolpidem
• Thyroxine
• Triiodothyronine