Association of <i>N-acetyltransferases 1 and 2</i> Polymorphisms with Susceptibility to Head and Neck Cancers—A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis
Hady Mohammadi,
Mehrnoush Momeni Roochi,
Masoud Sadeghi,
Ata Garajei,
Hosein Heidar,
Bayazid Ghaderi,
Jyothi Tadakamadla,
Ali Aghaie Meybodi,
Mohsen Dallband,
Sarton Mostafavi,
Melina Mostafavi,
Mojtaba Salehi,
Dena Sadeghi-Bahmani,
Serge Brand
Affiliations
Hady Mohammadi
Department of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, Health Services, Kurdistan University of Medical Sciences, Sanandaj 6617713446, Iran
Mehrnoush Momeni Roochi
Department of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, Iran
Masoud Sadeghi
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran
Ata Garajei
Department of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, Iran
Hosein Heidar
Department of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, Iran
Bayazid Ghaderi
Cancer and Immunology Research Center, Department of Internal Medicine, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj 6617913446, Iran
Jyothi Tadakamadla
School of Medicine and Dentistry, Griffith University, Brisbane, QLD 4222, Australia
Ali Aghaie Meybodi
Department of Head and Neck Surgical Oncology and Reconstructive Surgery, The Cancer Institute, School of Medicine, Tehran University of Medical Sciences, Tehran 1439955991, Iran
Mohsen Dallband
Department of Oral and Maxillofacial Surgery, Dental School, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran
Sarton Mostafavi
English Department, Baneh Branch, Islamic Azad University, Baneh 6691133845, Iran
Melina Mostafavi
Tehran Medical Branch, Islamic Azad University, Tehran 1419733171, Iran
Mojtaba Salehi
Department of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, Iran
Dena Sadeghi-Bahmani
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851115, Iran
Serge Brand
Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851115, Iran
Background and objective:N-acetyltransferases 1 and 2 (NAT1 and NAT2) genes have polymorphisms in accordance with slow and rapid acetylator phenotypes with a role in the development of head and neck cancers (HNCs). Herein, we aimed to evaluate the association of NAT1 and NAT2 polymorphisms with susceptibility to HNCs in an updated meta-analysis. Materials and methods: A search was comprehensively performed in four databases (Web of Science, Scopus, PubMed/Medline, and Cochrane Library until 8 July 2021). The effect sizes, odds ratio (OR) along with 95% confidence interval (CI) were computed. Trial sequential analysis (TSA), publication bias and sensitivity analysis were conducted. Results: Twenty-eight articles including eight studies reporting NAT1 polymorphism and twenty-five studies reporting NAT2 polymorphism were involved in the meta-analysis. The results showed that individuals with slow acetylators of NAT2 polymorphism are at higher risk for HNC OR: 1.22 (95% CI: 1.02, 1.46; p = 0.03). On subgroup analysis, ethnicity, control source, and genotyping methods were found to be significant factors in the association of NAT2 polymorphism with the HNC risk. TSA identified that the amount of information was not large enough and that more studies are needed to establish associations. Conclusions: Slow acetylators in NAT2 polymorphism were related to a high risk of HNC. However, there was no relationship between NAT1 polymorphism and the risk of HNC.
