Nature Communications (Oct 2016)
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
- Naoto Kubota,
- Tetsuya Kubota,
- Eiji Kajiwara,
- Tomokatsu Iwamura,
- Hiroki Kumagai,
- Taku Watanabe,
- Mariko Inoue,
- Iseki Takamoto,
- Takayoshi Sasako,
- Katsuyoshi Kumagai,
- Motoyuki Kohjima,
- Makoto Nakamuta,
- Masao Moroi,
- Kaoru Sugi,
- Tetsuo Noda,
- Yasuo Terauchi,
- Kohjiro Ueki,
- Takashi Kadowaki
Affiliations
- Naoto Kubota
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Tetsuya Kubota
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Eiji Kajiwara
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Tomokatsu Iwamura
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Hiroki Kumagai
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Taku Watanabe
- First Department of Medicine, Hokkaido University School of Medicine
- Mariko Inoue
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Iseki Takamoto
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Takayoshi Sasako
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Katsuyoshi Kumagai
- Animal Research Center, Tokyo Medical University
- Motoyuki Kohjima
- Department of Gastroenterology, Clinical Research Center, National Hospital Organization Kyushu Medical Center
- Makoto Nakamuta
- Department of Gastroenterology, Clinical Research Center, National Hospital Organization Kyushu Medical Center
- Masao Moroi
- Division of Cardiovascular Medicine, Toho University, Ohashi Hospital
- Kaoru Sugi
- Division of Cardiovascular Medicine, Toho University, Ohashi Hospital
- Tetsuo Noda
- Department of Cell Biology, Japanese Foundation for Cancer Research-Cancer Institute
- Yasuo Terauchi
- Department of Diabetes and Endocrinology, Yokohama City University, School of Medicine
- Kohjiro Ueki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Takashi Kadowaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/ncomms12977
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Type 2 diabetes and obesity are associated with increased hepatic gluconeogenesis and lipogenesis, known as selective insulin resistance. Here Kubota et al. explain selective insulin resistance in the liver with the zonal distribution and selective insulin-mediated regulation of Irs1 and Irs2.
