Long non-coding RNA and diseases

Abstract

Long non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation. They are widely involved in epigenetics, transcription, translation, modification and degradation, thereby affecting the life activities of the body, and their expression imbalance is closely related to the occurrence and development of diseases. Therefore, analyzing the inherent characteristics of lncRNA and revealing its intrinsic role can not only deepen our understanding of human physiological and pathological processes, but also provide new ideas and potential solutions for the diagnosis, prevention and treatment of diseases. So as to provide references for the related research of lncRNAs.

Keywords

• non-coding rna|tumors|nervous system|disease|epigenetics