Egyptian Pediatric Association Gazette (Oct 2024)

Egyptian pediatric kidney transplantation: highlights on post-transplant follow-up and management of complications by the Egyptian Pediatric Clinical Practice Guidelines Committee (EPG) Nephrology Group

  • Bahia Moustafa,
  • Neveen A. Soliman,
  • Ihab Shaheen,
  • Ahmed Badr,
  • Fatma M. Atia,
  • Mohamed K. El Hatw,
  • Engy Adel Mogahed,
  • Mona EL-Ghamrawy,
  • Khaled El Khashab,
  • Noha Shaheen,
  • Mohamad G. Shouman,
  • Abeer Selim,
  • Magdy El-Sharkawy,
  • Tarek Abd El Azeem,
  • Mohamad Esmat,
  • Manal Salman,
  • Bedeir Ali-El-Dein,
  • Mona Abdel Rahim,
  • Muhamed A. El-Hadedy,
  • Moatasem Elsayed Ghoneim,
  • Mai S. Korkor,
  • Tarek E. I. Omar,
  • Yasser Amer,
  • Ashraf Abdel Baky,
  • On Behalf of Egyptian Pediatric Clinical Practice Guideline Committee

DOI
https://doi.org/10.1186/s43054-024-00321-y
Journal volume & issue
Vol. 72, no. 1
pp. 1 – 21

Abstract

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Abstract Background Pediatric kidney transplantation is unique when compared to adults. They need optimum post-transplant care to achieve longer graft and patient survival. Infections, rejection, recurrence, malignancy, bone problems, hypertension, and surgical complications are the most important challenges that require prevention, early detection, and management. Chronic allograft nephropathy needs different approaches based on its related causes, allograft pathology, graft function, and availability of re-transplantation. Aim/objectives This national adapted guideline aims to frame evidence-based post-transplant recommendations adopted or adapted from EB source guidelines to optimize post-transplant patient care. Methods Our guideline is evidence based adapted from four national and international source guidelines with permissions [KDIGO 2020, RA/BTS 2022–2018, EAU 2018] that were appraised with AGREE II instrument tool. We followed the “adapted ADAPTE” CPG formal adaptation methodology that consists of 3 phases and 24 steps and tools. Virtual monthly meetings all through the year 2023 were activated for reviewing and validation of final adaptation of evidence-based guideline draft, considering all comments of external reviewers. This guideline was registered in the practice guideline registration for transparency (PREPARE), number: PREPARE-2023CN364. Results Recommendation statements in guidelines stand for results in articles. Discussion of important recommendations and the rationale behind selection of adopted statements and tailoring of others to suit our local facilities, expertise, and renal native disease profile was presented in the text with reasons and references. Conclusion The provided guidelines aim to improve graft and patient outcome through prevention and early management of complications and suggest research areas lacking validated research recommendations.

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