Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Agnieszka Adamska; Paulina Tomczuk-Bobik; Anna Beata Popławska-Kita; Katarzyna Siewko; Angelika Buczyńska; Piotr Szumowski; Łukasz Żukowski; Janusz Myśliwiec; Monika Zbucka-Krętowska; Marcin Adamski; Adam Jacek Krętowski

doi:10.1530/EC-21-0187

Endocrine Connections (Oct 2021)

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Agnieszka Adamska,
Paulina Tomczuk-Bobik,
Anna Beata Popławska-Kita,
Katarzyna Siewko,
Angelika Buczyńska,
Piotr Szumowski,
Łukasz Żukowski,
Janusz Myśliwiec,
Monika Zbucka-Krętowska,
Marcin Adamski,
Adam Jacek Krętowski

Affiliations

Agnieszka Adamska: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
Paulina Tomczuk-Bobik: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
Anna Beata Popławska-Kita: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
Katarzyna Siewko: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
Angelika Buczyńska: Clinical Research Centre, Medical University of Bialystok, Białystok, Poland
Piotr Szumowski: Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland
Łukasz Żukowski: Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland
Janusz Myśliwiec: Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland
Monika Zbucka-Krętowska: Department of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Bialystok, Białystok, Poland
Marcin Adamski: Faculty of Computer Science, Bialystok University of Technology, Białystok, Poland
Adam Jacek Krętowski: Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland; Clinical Research Centre, Medical University of Bialystok, Białystok, Poland

DOI: https://doi.org/10.1530/EC-21-0187
Journal volume & issue: Vol. 10, no. 10
pp. 1283 – 1290

Abstract

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Treatment with radioactive iodine (RAI) in women with differenti ated thyroid cancer is associated with decreased serum concentrations of anti-Mülle rian hormone (AMH); however, other markers have not been investigated. Therefore, t his study aimed to evaluate the effect of RAI treatment on antral follicle count (AFC) and the serum concentration of inhibin B, follicle-stimulating hormone (FSH), and AMH in women with papillary thyroid cancer (PTC) treated with RAI. We examined 25 women at a median age of 33 years treated with a single dose of RAI. We divided the p articipants into women over (n = 11) and under 35 years of age (n = 14). Serum concentrations of inhibin B, FSH, AMH, and AFC were assessed at baseline and 1 year after RAI treatmen t. We found decreased AFC (P = 0.03), serum levels of AMH (P < 0.01), inhibin B (P = 0.03), but not FSH (P = 0.23), 1 year after RAI treatment in comparison to baseline in the who le group. When we compared serum levels of AMH in younger vs older women separate ly, we observed a significant reduction of this hormone’s serum level after RAI tr eatment in both groups (P < 0.01; P = 0.04, respectively). We concluded that RAI treatment significan tly impacts the functional ovarian reserve in premenopausal women with PTC.

Published in Endocrine Connections

ISSN: 2049-3614 (Online)
Publisher: Bioscientifica
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: http://www.endocrineconnections.com/

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