Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer

Wedad Saeed Al-Qahtani; Ebtesam Al-Olayan; Fatimah Gh. Albani; Rania Saad Suliman; Nada Hamad Aljarba; E.M. Al-Humaidhi; Alanood S. Almurshedi; Dalia Mostafa Domiaty; Manal Abdullah Alduwish; Aljohara M. Al-Otaibi; Abdelbaset Mohamed Elasbali; Hussain Gadelkarim Ahmed; Bassam Ahmed Almutlaq

doi:10.1055/s-0040-1714415

Global Medical Genetics (Aug 2020)

Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer

Wedad Saeed Al-Qahtani,
Ebtesam Al-Olayan,
Fatimah Gh. Albani,
Rania Saad Suliman,
Nada Hamad Aljarba,
E.M. Al-Humaidhi,
Alanood S. Almurshedi,
Dalia Mostafa Domiaty,
Manal Abdullah Alduwish,
Aljohara M. Al-Otaibi,
Abdelbaset Mohamed Elasbali,
Hussain Gadelkarim Ahmed,
Bassam Ahmed Almutlaq

Affiliations

Wedad Saeed Al-Qahtani: Department of Forensic Sciences, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia
Ebtesam Al-Olayan: Department of Zoology, College of Science, King Saud University Riyadh, Riyadh, Saudi Arabia
Fatimah Gh. Albani: Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Rania Saad Suliman: Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Nada Hamad Aljarba: Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
E.M. Al-Humaidhi: Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Alanood S. Almurshedi: Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Dalia Mostafa Domiaty: Department of Biology, College of Science, Jeddah University, Jeddah, Saudi Arabia
Manal Abdullah Alduwish: Department of Biology, Prince Sattam bin Abdulaziz University, College of Science and Humanities, Alkarj, Saudi Arabia
Aljohara M. Al-Otaibi: Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
Abdelbaset Mohamed Elasbali: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Qurayyat, Saudi Arabia
Hussain Gadelkarim Ahmed: College of Medicine, University of Hail, Hail, Saudi Arabia
Bassam Ahmed Almutlaq: College of Medicine, University of Hail, Hail, Saudi Arabia

DOI: https://doi.org/10.1055/s-0040-1714415
Journal volume & issue: Vol. 07, no. 02
pp. 035 – 040

Abstract

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Background Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM). Materials and Methods Data from 315 cases (156 colon diabetics and 159 patients were nondiabetics) were retrospectively retrieved. mRNA from surgically resected colon cancer tumors were also retrieved. Results The expression of KRAS mRNA was significantly higher in patients afflicted with T2DM than nondiabetic patients. The KRAS mRNA levels were significantly amplified from primary to metastatic lesions (p < 0.001). Conclusion The association between T2DM and colon cancer was well-established in the present study.

Published in Global Medical Genetics

ISSN: 2699-9404 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Science: Biology (General): Genetics; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.thieme.com/books-main/genetics/product/5705-global-medical-genetics

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