Nature Communications (Feb 2017)
The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
- Zenggang Li,
- Andrei A. Ivanov,
- Rina Su,
- Valentina Gonzalez-Pecchi,
- Qi Qi,
- Songlin Liu,
- Philip Webber,
- Elizabeth McMillan,
- Lauren Rusnak,
- Cau Pham,
- Xiaoqian Chen,
- Xiulei Mo,
- Brian Revennaugh,
- Wei Zhou,
- Adam Marcus,
- Sahar Harati,
- Xiang Chen,
- Margaret A. Johns,
- Michael A. White,
- Carlos S. Moreno,
- Lee A. D. Cooper,
- Yuhong Du,
- Fadlo R. Khuri,
- Haian Fu
Affiliations
- Zenggang Li
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Andrei A. Ivanov
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Rina Su
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Valentina Gonzalez-Pecchi
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Qi Qi
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Songlin Liu
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Philip Webber
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Elizabeth McMillan
- Department of Cell Biology, University of Texas Southwestern Medical Center
- Lauren Rusnak
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Cau Pham
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Xiaoqian Chen
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Xiulei Mo
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Brian Revennaugh
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Wei Zhou
- Department of Hematology & Medical Oncology, Emory University
- Adam Marcus
- Department of Hematology & Medical Oncology, Emory University
- Sahar Harati
- Department of Biomedical Informatics, Emory University School of Medicine
- Xiang Chen
- Department of Dermatology, Xiangya Hospital, Central South University
- Margaret A. Johns
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Michael A. White
- Department of Cell Biology, University of Texas Southwestern Medical Center
- Carlos S. Moreno
- Winship Cancer Institute, Emory University
- Lee A. D. Cooper
- Winship Cancer Institute, Emory University
- Yuhong Du
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- Fadlo R. Khuri
- Department of Hematology & Medical Oncology, Emory University
- Haian Fu
- Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University
- DOI
- https://doi.org/10.1038/ncomms14356
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Understanding of dysregulation in cancers requires knowledge, beyond cancer genomes, of the interactions of cancer-associated proteins. Here, the authors use high-throughput, time-resolved FRET to map protein–protein interactions to establish a lung cancer protein network, and demonstrate its utility in revealing new oncogenic pathways and connectivity of tumour suppressors with druggable targets.
