The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis

Abstract

Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2O2). H2O2 then reacts with ferrous iron, generating hydroxyl radicals that cause peroxidation of polyunsaturated-fatty-acid chains of membrane phospholipids, resulting in plasma membrane rupture and ferroptosis.

Keywords

• ferroptosis
• oxidoreductase
• por
• cyb5r1
• lipid peroxidation
• h2o2
• hydroxyl radicals
• pufa
• gpx4
• fsp1