α3 Chains of type V collagen regulate breast tumour growth via glypican-1

Guorui Huang; Gaoxiang Ge; Valerio Izzi; Daniel S. Greenspan

doi:10.1038/ncomms14351

Nature Communications (Jan 2017)

α3 Chains of type V collagen regulate breast tumour growth via glypican-1

Guorui Huang,
Gaoxiang Ge,
Valerio Izzi,
Daniel S. Greenspan

Affiliations

Guorui Huang: Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health
Gaoxiang Ge: Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health
Valerio Izzi: Centre of Excellence in Cell-Extracellular Matrix Research and Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
Daniel S. Greenspan: Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health

DOI: https://doi.org/10.1038/ncomms14351
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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Collagen has a role in cancer and is particularly important for breast cancer. Here the authors show that the expression of α3 type V collagen and one of its receptors- glipican-1- in the same cell, contributes to a deregulated growth of breast cancer cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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