Nature Communications (Oct 2018)
Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
Abstract
In vitro expansion of human epidermal keratinocytes to resurface severe wound defects still relies on a human/mouse xenograft culture system. Here the authors develop a fully human, xeno-free culture system using skin-associated laminins, normally present in vivo, to replace mouse feeder cells.