Intelligent Wireless EEG Measurement System With Electrical and Optogenetic Stimulation for Epileptic Seizure Detection and Suppression

Wei-En Lee; Chieh Tsou; Zhan-Xian Liao; Po-Yen Lu; Tsung-Hsien Lin; Shuenn-Yuh Lee; Chou-Ching K. Lin; Gia-Shing Shieh

doi:10.1109/ACCESS.2021.3083772

IEEE Access (Jan 2021)

Intelligent Wireless EEG Measurement System With Electrical and Optogenetic Stimulation for Epileptic Seizure Detection and Suppression

Wei-En Lee,
Chieh Tsou,
Zhan-Xian Liao,
Po-Yen Lu,
Tsung-Hsien Lin,
Shuenn-Yuh Lee,
Chou-Ching K. Lin,
Gia-Shing Shieh

Affiliations

Wei-En Lee: Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
Chieh Tsou: ORCiD; Department of Electrical Engineering, National Cheng Kung University, Tainan City, Taiwan
Zhan-Xian Liao: ORCiD; Department of Electrical Engineering, National Cheng Kung University, Tainan City, Taiwan
Po-Yen Lu: Department of Mechanical Engineering, National Cheng Kung University, Tainan City, Taiwan
Tsung-Hsien Lin: ORCiD; Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
Shuenn-Yuh Lee: ORCiD; Department of Electrical Engineering, National Cheng Kung University, Tainan City, Taiwan
Chou-Ching K. Lin: ORCiD; Division of Neurology, National Cheng-Kung University Hospital, Tainan City, Taiwan
Gia-Shing Shieh: Division of Urology, Ministry of Health and Welfare Tainan Hospital, Tainan City, Taiwan

DOI: https://doi.org/10.1109/ACCESS.2021.3083772
Journal volume & issue: Vol. 9
pp. 80264 – 80274

Abstract

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A two-channel real-time intelligent electroencephalography (EEG) measurement system with electrical and optical stimulations is presented for seizure detection and suppression. Based on software control through a wireless interface, this system provides closed- and open-loop feedback control with programmable waveform for electrical and optical stimulations. Matlab graphical user interface is used to monitor the intracranial EEG, perform the algorithm for seizure detection, and adjust the required intensity, frequency, duty cycle, and duration of electrical and optical stimulations. The whole hardware device is embedded on a printed circuit board with the size of 27.3 mm $\times23.6$ mm. C57BL/6 mice with Thy1-ChR2-YFP gene transfer and drug-induced seizure are used to demonstrate epileptic seizure suppression according to electrical and optogenetic stimulation in the proposed wireless EEG measurement system.

Published in IEEE Access

ISSN: 2169-3536 (Online)
Publisher: IEEE
Country of publisher: United States
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering
Website: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=6287639

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