Secular variations of the vertical geomagnetic field at Paratunka (Kamchatka), Kakioka (Honshu), Mamambetsu (Hokkaido) and Patrony (Irkutsk) are considered from 1968 to 2014. Comparative analysis of secular variations showed that from 1968 to 2001, similar variations with the intensity of first hundreds on nT are obvious at four observatories. For the following period from 2001 to 2014, the secular variation at Paratunka observatory differs from other observatories. This disagreement of the secular geomagnetic variation at Paratunka observatory is timed to the increase of seismicity at the depth of 400-700 km in South Kamchatka region. It is suggested that in the result of increase of the seismicity in the region of transition from the upper to lower mantle, physical and chemical processes became more active. That caused formation of a large geo-electrical inhomogeneity which affected the behavior of the vertical component of geomagnetic field.