306 N-glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy

• Alice Bergamini,
• Barbara Camisa,
• Fabio Ciceri,
• Chiara Bonini,
• Monica Casucci,
• Beatrice Greco,
• Federica Pedica,
• Chiara Balestrieri,
• Laura Falcone,
• Miriam Redegalli,
• Elena Tiziano,
• Camilla Sirini,
• Giovanni Tonon,
• Rita El Khoury,
• Oronzina Botrugno

Affiliations

Alice Bergamini

1 Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Milano, Italy

Barbara Camisa

Aff5 0000000417581884grid.18887.3eInnovative Immunotherapies UnitIRCCS San Raffaele Scientific Institute Milan Italy

Fabio Ciceri

4Hematology and Bone Marrow Transplant Unit – San Raffaele Hospital, Milan, Italy

Chiara Bonini

2 Division of Immunology, Transplantation and Infectious Disease, IRCCS Ospedale San Raffaele, Milano, Italy

Monica Casucci

1IRCCS San Raffaele Scientific Institute, Milan, Italy

Beatrice Greco

4Merck Global Health Institute, Eysins, Switzerland

Federica Pedica

16 Department of Pathology, San Raffaele Scientific Institute, Milan, Italy

Chiara Balestrieri

3 Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy

Laura Falcone

Innovative Immunotherapies Unit, IRCCS Ospedale San Raffaele, Milan, Italy

Miriam Redegalli

1IRCCS San Raffaele Scientific Institute, Milan, Italy

Elena Tiziano

Experimental Hematology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

Camilla Sirini

1IRCCS San Raffaele Scientific Institute, Milan, Italy

Giovanni Tonon

Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy

Rita El Khoury

1Università Vita-Salute San Raffaele, Milan, Italy

Oronzina Botrugno

1IRCCS San Raffaele Scientific Institute, Milan, Italy