Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation

Abstract

Redweik et al. explore mechanisms underlying the effects of reserpine treatment on Salmonella-infected explants from chicken intestine as well as the effects on the intestine in vivo following oral treatment. They demonstrate that several signaling pathways (norepinephrine, mTOR, epidermal growth factor) contribute to these reserpine-induced antimicrobial responses, with MEK1/2 playing a central role.