ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT

• Mark Hartmann,
• Maximilian Schönung,
• Jovana Rajak,
• Joschka Hey,
• Valentin Maurer,
• Ling Hai,
• Sina Staeble,
• Jens Langstein,
• Katharina Bauer,
• Mariam Hakobyan,
• Laura Jardine,
• Sheila Bohler,
• Dominik Vonficht,
• Abdul-Habib Maag,
• Dirk Lebrecht,
• Katrin M. Bernt,
• Roland Roelz,
• Tobias Boch,
• Eleonora Khabirova,
• Pavlo Lutsik,
• Simon Haas,
• Muzlifah Haniffa,
• Sam Behjati,
• Jan-Philipp Mallm,
• Christian Buske,
• Michael D. Milsom,
• Stefan Fröhling,
• Marc-Jan Bonder,
• Charlotte Niemeyer,
• Christian Flotho,
• Christoph Plass,
• Miriam Erlacher,
• Matthias Schlesner,
• Daniel B. Lipka

Affiliations

Mark Hartmann

Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany

Maximilian Schönung

Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany

Jovana Rajak

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Joschka Hey

Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Valentin Maurer

Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany

Ling Hai

Department of Neurology and Neurooncology, University Hospital Heidelberg, Heidelberg, Germany

Sina Staeble

Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany

Jens Langstein

Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany

Katharina Bauer

scOPEN Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany

Mariam Hakobyan

Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany

Laura Jardine

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Sheila Bohler

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Dominik Vonficht

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

Abdul-Habib Maag

Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany

Dirk Lebrecht

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Katrin M. Bernt

Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, USA

Roland Roelz

Department of Neurosurgery, University of Freiburg, Faculty of Medicine, Medical Center, Freiburg, Germany

Tobias Boch

Department of Hematology and Oncology, Heidelberg University, University Hospital Mannheim, Mannheim, Germany

Eleonora Khabirova

Wellcome Sanger Institute, Hinxton, UK

Pavlo Lutsik

Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Simon Haas

Berlin Institute of Health (BIH), Charité - Universitätsmedizin Berlin, Berlin, Germany

Muzlifah Haniffa

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Sam Behjati

Wellcome Sanger Institute, Hinxton, UK

Jan-Philipp Mallm

scOPEN Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany

Christian Buske

Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany

Michael D. Milsom

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Stefan Fröhling

Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg & German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany

Marc-Jan Bonder

Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, European Molecular Biology Laboratory (EMBL), Hinxton, United Kingdom

Charlotte Niemeyer

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Christian Flotho

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany

Christoph Plass

Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Miriam Erlacher

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany

Matthias Schlesner

Faculty of Applied Computer Sciences, Biomedical Informatics, Data Mining and Data Analytics, University of Augsburg, Augsburg, Germany

Daniel B. Lipka

Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany