Journal of Pharmacological Sciences (Jan 2007)

Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D1-Like Receptors in Mice

  • Eun-Joo Shin,
  • Ji Hoon Jeong,
  • Hyun Ji Kim,
  • Choon-Gon Jang,
  • Kiyofumi Yamada,
  • Toshitaka Nabeshima,
  • Hyoung-Chun Kim

DOI
https://doi.org/10.1254/jphs.sc0070348
Journal volume & issue
Vol. 105, no. 4
pp. 367 – 371

Abstract

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We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF–induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D1-like receptor antagonist, but not with sulpiride, a dopaminergic D2-like receptor antagonist, inhibited ELF-MF–induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF–induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors. Keywords:: extremely low frequency magnetic field, locomotor activity, dopaminergic receptor